DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

The DNA replication machinery is an important target for antibiotic development for increasingly drug resistant bacteria including Mycobacterium tuberculosis(1). While blocking DNA replication leads to cell death, disrupting the processes used to ensure replication fidelity can accelerate mutation a...

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Udgivet i:Nat Genet
Main Authors: Rock, Jeremy M., Lang, Ulla F., Chase, Michael R., Ford, Christopher B., Gerrick, Elias R., Gawande, Richa, Coscolla, Mireia, Gagneux, Sebastien, Fortune, Sarah M., Lamers, Meindert H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449270/
https://ncbi.nlm.nih.gov/pubmed/25894501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3269
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