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DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

The DNA replication machinery is an important target for antibiotic development for increasingly drug resistant bacteria including Mycobacterium tuberculosis(1). While blocking DNA replication leads to cell death, disrupting the processes used to ensure replication fidelity can accelerate mutation a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Genet
Prif Awduron: Rock, Jeremy M., Lang, Ulla F., Chase, Michael R., Ford, Christopher B., Gerrick, Elias R., Gawande, Richa, Coscolla, Mireia, Gagneux, Sebastien, Fortune, Sarah M., Lamers, Meindert H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449270/
https://ncbi.nlm.nih.gov/pubmed/25894501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3269
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