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Stereospecific Formation of E- and Z- Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase

The dehydratase domain FosDH1 from module 1 of the fostriecin polyketide synthase (PKS) catalyzed the stereospecific interconversion of (3R)-3-hydroxybutyryl-FosACP1 (5) and (E)-2-butenoyl-FosACP1 (11), as established by a combination of direct LC-MS/MS and chiral GC-MS. FosDH1 did not act on either...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Shah, Dhara D., You, Young-Ok, Cane, David E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636686/
https://ncbi.nlm.nih.gov/pubmed/28902510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08896
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