IL-21 RECEPTOR SIGNALING IS ESSENTIAL FOR OPTIMAL CD4+ T-CELL FUNCTION AND CONTROL OF Mycobacterium tuberculosis INFECTION IN MICE

In the current study we determined the role of IL-21 receptor signaling in Mycobacterium tuberculosis (Mtb) infection, using IL-21 receptor knockout (IL-21R KO) mice. Fifty percent of Mtb H37Rv infected IL-21R KO mice died in six months compared to no deaths in infected wild type (WT) mice. Mtb infe...

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Veröffentlicht in:J Immunol
Hauptverfasser: Cheekatla, Satyanarayana Swamy, Tripathi, Deepak, Venkatasubramanian, Sambasivan, Paidipally, Padmaja, Welch, Elwyn, Tvinnereim, Amy R, Nurieva, Roza, Vankayalapati, Ramakrishna
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636679/
https://ncbi.nlm.nih.gov/pubmed/28855309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601231
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