Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1

IDH1 mutation is the earliest genetic alteration in low-grade gliomas (LGGs), but its role in tumor recurrence is unclear. Mutant IDH1 drives overproduction of the oncometabolite d-2-hydroxyglutarate (2HG) and a CpG island (CGI) hypermethylation phenotype (G-CIMP). To investigate the role of mutant...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Mazor, Tali, Chesnelong, Charles, Pankov, Aleksandr, Jalbert, Llewellyn E., Hong, Chibo, Hayes, Josie, Smirnov, Ivan V., Marshall, Roxanne, Souza, Camila F., Shen, Yaoqing, Viswanath, Pavithra, Noushmehr, Houtan, Ronen, Sabrina M., Jones, Steven J. M., Marra, Marco A., Cairncross, J. Gregory, Perry, Arie, Nelson, Sarah J., Chang, Susan M., Bollen, Andrew W., Molinaro, Annette M., Bengtsson, Henrik, Olshen, Adam B., Weiss, Samuel, Phillips, Joanna J., Luchman, H. Artee, Costello, Joseph F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2017
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635900/
https://ncbi.nlm.nih.gov/pubmed/28916733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708914114
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