MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia

Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax fa...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Rassenti, Laura Z., Balatti, Veronica, Ghia, Emanuela M., Palamarchuk, Alexey, Tomasello, Luisa, Fadda, Paolo, Pekarsky, Yuri, Widhopf, George F., Kipps, Thomas J., Croce, Carlo M.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635897/
https://ncbi.nlm.nih.gov/pubmed/28923920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708264114
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