MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia

Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax fa...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Rassenti, Laura Z., Balatti, Veronica, Ghia, Emanuela M., Palamarchuk, Alexey, Tomasello, Luisa, Fadda, Paolo, Pekarsky, Yuri, Widhopf, George F., Kipps, Thomas J., Croce, Carlo M.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635897/
https://ncbi.nlm.nih.gov/pubmed/28923920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708264114
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