Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis

Skeletal metastases, the leading cause of death in advanced breast cancer patients, depend on tumor cell interactions with the mineralized bone extracellular matrix. Bone mineral is largely composed of hydroxyapatite (HA) nanocrystals with physicochemical properties that vary significantly by anatom...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: He, Frank, Chiou, Aaron E., Loh, Hyun Chae, Lynch, Maureen, Seo, Bo Ri, Song, Young Hye, Lee, Min Joon, Hoerth, Rebecca, Bortel, Emely L., Willie, Bettina M., Duda, Georg N., Estroff, Lara A., Masic, Admir, Wagermaier, Wolfgang, Fratzl, Peter, Fischbach, Claudia
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
Physical Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635895/
https://ncbi.nlm.nih.gov/pubmed/28923958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708161114
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