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Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis

Skeletal metastases, the leading cause of death in advanced breast cancer patients, depend on tumor cell interactions with the mineralized bone extracellular matrix. Bone mineral is largely composed of hydroxyapatite (HA) nanocrystals with physicochemical properties that vary significantly by anatom...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: He, Frank, Chiou, Aaron E., Loh, Hyun Chae, Lynch, Maureen, Seo, Bo Ri, Song, Young Hye, Lee, Min Joon, Hoerth, Rebecca, Bortel, Emely L., Willie, Bettina M., Duda, Georg N., Estroff, Lara A., Masic, Admir, Wagermaier, Wolfgang, Fratzl, Peter, Fischbach, Claudia
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635895/
https://ncbi.nlm.nih.gov/pubmed/28923958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708161114
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