Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis

Skeletal metastases, the leading cause of death in advanced breast cancer patients, depend on tumor cell interactions with the mineralized bone extracellular matrix. Bone mineral is largely composed of hydroxyapatite (HA) nanocrystals with physicochemical properties that vary significantly by anatom...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: He, Frank, Chiou, Aaron E., Loh, Hyun Chae, Lynch, Maureen, Seo, Bo Ri, Song, Young Hye, Lee, Min Joon, Hoerth, Rebecca, Bortel, Emely L., Willie, Bettina M., Duda, Georg N., Estroff, Lara A., Masic, Admir, Wagermaier, Wolfgang, Fratzl, Peter, Fischbach, Claudia
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Physical Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635895/
https://ncbi.nlm.nih.gov/pubmed/28923958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708161114
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