Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis

Skeletal metastases, the leading cause of death in advanced breast cancer patients, depend on tumor cell interactions with the mineralized bone extracellular matrix. Bone mineral is largely composed of hydroxyapatite (HA) nanocrystals with physicochemical properties that vary significantly by anatom...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: He, Frank, Chiou, Aaron E., Loh, Hyun Chae, Lynch, Maureen, Seo, Bo Ri, Song, Young Hye, Lee, Min Joon, Hoerth, Rebecca, Bortel, Emely L., Willie, Bettina M., Duda, Georg N., Estroff, Lara A., Masic, Admir, Wagermaier, Wolfgang, Fratzl, Peter, Fischbach, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635895/
https://ncbi.nlm.nih.gov/pubmed/28923958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708161114
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