NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor

Nuclear receptor corepressor 1 (NCoR1) is considered to be the major corepressor that mediates ligand-independent actions of the thyroid hormone receptor (TR) during development and in hypothyroidism. We tested this by expressing a hypomorphic NCoR1 allele (NCoR1ΔID), which cannot interact with the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mendoza, Arturo, Astapova, Inna, Shimizu, Hiroaki, Gallop, Molly R., Al-Sowaimel, Lujain, MacGowan, S. M. Dileas, Bergmann, Tim, Berg, Anders H., Tenen, Danielle E., Jacobs, Christopher, Lyubetskaya, Anna, Tsai, Linus, Hollenberg, Anthony N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635887/
https://ncbi.nlm.nih.gov/pubmed/28923959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706917114
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