Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit

MicroRNAs (miRNAs) have been known to affect various biological processes by repressing expression of specific genes. Here we describe an essential function of the miR-34/449 family during differentiation of epithelial cells. We found that miR-34/449 suppresses the cell-cycle machinery in vivo and p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Otto, Tobias, Candido, Sheyla V., Pilarz, Mary S., Sicinska, Ewa, Bronson, Roderick T., Bowden, Michaela, Lachowicz, Iga A., Mulry, Kristin, Fassl, Anne, Han, Richard C., Jecrois, Emmanuelle S., Sicinski, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635871/
https://ncbi.nlm.nih.gov/pubmed/28923932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702914114
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