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Boundary problem in Simon’s two-stage clinical trial designs
The activity of a new treatment in clinical trials with binary endpoints can be assessed by comparing the observed response rate to the target response rate. Traditionally, a one-sided hypothesis is used to make statistical inference, and the actual type I error rate has to be computed over the para...
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| Veröffentlicht in: | J Biopharm Stat |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635844/ https://ncbi.nlm.nih.gov/pubmed/26881325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2016.1148716 |
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