Influence of Diabetes on Plasma Pharmacokinetics and Brain Bioavailability of Grape Polyphenols and their Phase II Metabolites in the Zucker Diabetic Fatty Rat

SCOPE: The effect of diabetes on the pharmacokinetics, bioavailability and brain distribution of grape polyphenols and select metabolites was studied in the Zucker diabetic fatty (ZDF) rat model. METHODS AND RESULTS: (ZDF) rats and their lean controls (LN) were dosed with a Standardized Grape Polyph...

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Udgivet i:Mol Nutr Food Res
Main Authors: Chen, Tzu-Ying, Ferruzzi, Mario G., Wu, Qing-Li, Simon, James E., Talcott, Stephen T., Wang, Jun, Ho, Lap, Todd, George, Cooper, Bruce, Pasinetti, Giulio M., Janle, Elsa M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635601/
https://ncbi.nlm.nih.gov/pubmed/28568316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201700111
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