Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: Implications for treatment in Alzheimer’s Disease

The present study explored the bioavailability and brain deposition of a Grape Seed Polyphenolic Extract (GSPE) previously found to attenuate cognitive deterioration in a mouse model of Alzheimer’s disease (AD). Plasma pharmacokinetic response of major GSPE phenolic components was measured following...

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Detalhes bibliográficos
Main Authors: Ferruzzi, Mario G., Lobo, Jessica K., Janle, Elsa M., Whittaker, Naomi, Cooper, Bruce, Simon, James E., Wu, Qing-Li, Welch, Cara, Ho, Lap, Weaver, Connie, Pasinetti, Giulio M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801429/
https://ncbi.nlm.nih.gov/pubmed/19625746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-1135
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