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Distinct Signaling Patterns of Allosteric Antagonism at the P2Y(1) Receptor
Traditionally, G protein–coupled receptor antagonists are classified as competitive or noncompetitive and surmountable or insurmountable based on functional antagonism. P2Y(1) receptor (P2Y(1)R) structures showed two antagonists binding to two spatially distinct sites: nucleotide MRS2500 (orthosteri...
Shranjeno v:
| izdano v: | Mol Pharmacol |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635520/ https://ncbi.nlm.nih.gov/pubmed/28864555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.109660 |
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