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Prostaglandin E(2) Inhibits Histamine-Evoked Ca(2+) Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signaling Junctions and Protein Kinase A
In human aortic smooth muscle cells, prostaglandin E(2) (PGE(2)) stimulates adenylyl cyclase (AC) and attenuates the increase in intracellular free Ca(2+) concentration evoked by activation of histamine H(1) receptors. The mechanisms are not resolved. We show that cAMP mediates inhibition of histami...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635517/ https://ncbi.nlm.nih.gov/pubmed/28877931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.109249 |
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