The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

OBJECTIVE: Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor kappa-beta (NFκB)-mediated inflammation, which drives post-interventional intimal hyperplasia development. We studied the contrib...

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Foilsithe in:PLoS One
Main Authors: de Jong, Rob C. M., Ewing, Mark M., de Vries, Margreet R., Karper, Jacco C., Bastiaansen, Antonius J. N. M., Peters, Hendrika A. B., Baghana, Fabiana, van den Elsen, Peter J., Gongora, Céline, Jukema, J. Wouter, Quax, Paul H. A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634597/
https://ncbi.nlm.nih.gov/pubmed/29016683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185820
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