The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

OBJECTIVE: Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor kappa-beta (NFκB)-mediated inflammation, which drives post-interventional intimal hyperplasia development. We studied the contrib...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: de Jong, Rob C. M., Ewing, Mark M., de Vries, Margreet R., Karper, Jacco C., Bastiaansen, Antonius J. N. M., Peters, Hendrika A. B., Baghana, Fabiana, van den Elsen, Peter J., Gongora, Céline, Jukema, J. Wouter, Quax, Paul H. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634597/
https://ncbi.nlm.nih.gov/pubmed/29016683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185820
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