P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3(*)Leiden Mice via Systemic Inhibition of Regulatory T Cells

Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficienc...

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Detalhes bibliográficos
Publicado no:Front Cardiovasc Med
Main Authors: de Jong, Alwin, de Jong, Rob C. M., Peters, Erna A., Arens, Ramon, Jukema, J. Wouter, de Vries, Margreet R., Quax, Paul H. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cardiovascular Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7874080/
https://ncbi.nlm.nih.gov/pubmed/33585580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2020.604821
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