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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

The Janus kinase (JAK), signal transducer of activation (STAT) pathway, discovered by investigating interferon gene induction, is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides a...

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Bibliografiska uppgifter
I publikationen:Annu Rev Med
Huvudupphovsmän: O’Shea, John J., Schwartz, Daniella M., Villarino, Alejandro V., Gadina, Massimo, McInnes, Iain B., Laurence, Arian
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634336/
https://ncbi.nlm.nih.gov/pubmed/25587654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-med-051113-024537
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