Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

Activation of Ras signalling occurs in ~30% of human cancers; however, activated Ras alone is not sufficient for tumourigenesis. In a screen for tumour suppressors that cooperate with oncogenic Ras (Ras(V12)) in Drosophila, we identified genes involved in the autophagy pathway. Bioinformatic analysi...

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Bibliographische Detailangaben
Veröffentlicht in:Oncogene
Hauptverfasser: Manent, J, Banerjee, S, de Matos Simoes, R, Zoranovic, T, Mitsiades, C, Penninger, J M, Simpson, K J, Humbert, P O, Richardson, H E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633656/
https://ncbi.nlm.nih.gov/pubmed/28581519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.175
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