The ATAD2 bromodomain binds different acetylation marks on the histone H4 in similar fuzzy complexes

Bromodomains are protein modules adopting conserved helix bundle folds. Some bromodomain-containing proteins, such as ATPase family AAA domain-containing protein 2 (ATAD2), isoform A, have attracted much interest because they are overexpressed in many types of cancer. Bromodomains bind to acetylated...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Langini, Cassiano, Caflisch, Amedeo, Vitalis, Andreas
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633134/
https://ncbi.nlm.nih.gov/pubmed/28798233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786350
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