Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase–IRF3 transcription factor interaction and signaling required for interferon induction

Heartland virus (HRTV) is a pathogenic phlebovirus related to the severe fever with thrombocytopenia syndrome virus (SFTSV), another phlebovirus causing life-threatening disease in humans. Previous findings have suggested that SFTSV can antagonize the host interferon (IFN) system via viral nonstruct...

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Vydáno v:J Biol Chem
Hlavní autoři: Ning, Yun-Jia, Feng, Kuan, Min, Yuan-Qin, Deng, Fei, Hu, Zhihong, Wang, Hualin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633133/
https://ncbi.nlm.nih.gov/pubmed/28848048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805127
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