The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor

The function of protein products generated from intramembraneous cleavage by the γ-secretase complex is not well defined. The γ-secretase complex is responsible for the cleavage of several transmembrane proteins, most notably the amyloid precursor protein that results in Aβ, a transmembrane (TM) pep...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Saadipour, Khalil, MacLean, Michael, Pirkle, Sean, Ali, Solav, Lopez-Redondo, Maria-Luisa, Stokes, David L., Chao, Moses V.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633122/
https://ncbi.nlm.nih.gov/pubmed/28821608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788729
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