Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

Pregnane X receptor (PXR) which belongs to the nuclear hormone receptor superfamily plays vital roles in several biological functions, especially in the inflammatory procedure. Besides that, PXR is revealed by recent studies to have essential effects on bone tissue. As an agonist of PXR, meclizine i...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Guo, Jiachao, Li, Weijin, Wu, Yingxing, Jing, Xingzhi, Huang, Junming, Zhang, Jiaming, Xiang, Wei, Ren, Ranyue, Lv, Zhengtao, Xiao, Jun, Guo, Fengjing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632684/
https://ncbi.nlm.nih.gov/pubmed/29046637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00693
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