Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

Pregnane X receptor (PXR) which belongs to the nuclear hormone receptor superfamily plays vital roles in several biological functions, especially in the inflammatory procedure. Besides that, PXR is revealed by recent studies to have essential effects on bone tissue. As an agonist of PXR, meclizine i...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Guo, Jiachao, Li, Weijin, Wu, Yingxing, Jing, Xingzhi, Huang, Junming, Zhang, Jiaming, Xiang, Wei, Ren, Ranyue, Lv, Zhengtao, Xiao, Jun, Guo, Fengjing
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632684/
https://ncbi.nlm.nih.gov/pubmed/29046637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00693
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