VT-1598 Inhibits the in vitro Growth of Mucosal Candida Isolates and Protects Against Oropharyngeal Candidiasis in IL-17 Deficient Mice

BACKGROUND: Patients with chronic mucocutaneous candidiasis (CMC) often develop azole-resistant Candida infections, making treatment difficult due to lack of oral antifungal drug options. VT-1598 is a novel broad-spectrum fungal CYP51 inhibitor designed for exquisite selectivity for the fungal targe...

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Pubblicato in:Open Forum Infect Dis
Autori principali: Break, Timothy J, Desai, Jigar V, Natarajan, Mukil, Ferre, Elise, Henderson, Christina, Zelazny, Adrian M, Yates, Christopher M, Cohen, Oren J, Schotzinger, Robert J, Garvey, Edward P, Lionakis, Michail
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632136/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.132
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