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Absorption, Distribution, and Excretion of (14)C-APX001 after Single-Dose Administration to Rats and Monkeys

BACKGROUND: APX001 is a small-molecule therapeutic agent in clinical development for the treatment of invasive fungal infections (IFI). METHODS: The absorption, distribution and excretion profiles of [(14)C]APX001-derived radioactivity were determined in rats (albino and pigmented) and monkeys. Rats...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Mansbach, Robert, Shaw, Karen J, Hodges, Michael R, Coleman, Samantha, Fitzsimmons, Michael E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5631253/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1209
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