5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers

DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene expression in mammals. Given their prevalence in the human genome, close correlation with gene expression and high chemical stability, these DNA epigenetic marks could...

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Bibliografske podrobnosti
izdano v:Cell Res
Main Authors: Li, Wenshuai, Zhang, Xu, Lu, Xingyu, You, Lei, Song, Yanqun, Luo, Zhongguang, Zhang, Jun, Nie, Ji, Zheng, Wanwei, Xu, Diannan, Wang, Yaping, Dong, Yuanqiang, Yu, Shulin, Hong, Jun, Shi, Jianping, Hao, Hankun, Luo, Fen, Hua, Luchun, Wang, Peng, Qian, Xiaoping, Yuan, Fang, Wei, Lianhuan, Cui, Ming, Zhang, Taiping, Liao, Quan, Dai, Menghua, Liu, Ziwen, Chen, Ge, Meckel, Katherine, Adhikari, Sarbani, Jia, Guifang, Bissonnette, Marc B, Zhang, Xinxiang, Zhao, Yupei, Zhang, Wei, He, Chuan, Liu, Jie
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630683/
https://ncbi.nlm.nih.gov/pubmed/28925386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.121
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