A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease

iNKT cells play important roles in immune regulation by bridging the innate and acquired immune systems. The functions of iNKT cells have been investigated in mice lacking the Traj18 gene segment that were generated by traditional embryonic stem cell technology, but these animals contain a biased T...

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Publicado no:Sci Rep
Main Authors: Ren, Yue, Sekine-Kondo, Etsuko, Shibata, Risa, Kato-Itoh, Megumi, Umino, Ayumi, Yanagida, Ayaka, Satoh, Masashi, Inoue, Komaki, Yamaguchi, Tomoyuki, Mochida, Keiichi, Nakae, Susumu, Van Kaer, Luc, Iwabuchi, Kazuya, Nakauchi, Hiromitsu, Watarai, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630609/
https://ncbi.nlm.nih.gov/pubmed/28986544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12475-4
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