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The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition

The deposition of the activating H3K4me3 and repressive H3K27me3 histone modifications within the same promoter, forming a so-called bivalent domain, maintains gene expression in a repressed but transcription-ready state. We recently reported a significantly increased incidence of bivalency followin...

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Publicado en:Oncotarget
Autores principales: Taube, Joseph H., Sphyris, Nathalie, Johnson, Kelsey S., Reisenauer, Keighley N., Nesbit, Taylor A., Joseph, Robiya, Vijay, Geraldine V., Sarkar, Tapasree R., Bhangre, Neeraja A., Song, Joon Jin, Chang, Jeffrey T., Lee, Min Gyu, Soundararajan, Rama, Mani, Sendurai A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630352/
https://ncbi.nlm.nih.gov/pubmed/29029452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19214
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