Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance

Histone H3 lysine 9 (H3K9) methylation is a hallmark of heterochromatin. H3K9 demethylation is crucial in mouse sex determination; The H3K9 demethylase Jmjd1a deficiency leads to increased H3K9 methylation at the Sry locus in embryonic gonads, thereby compromising Sry expression and causing male-to-...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Kuroki, Shunsuke, Okashita, Naoki, Baba, Shoko, Maeda, Ryo, Miyawaki, Shingo, Yano, Masashi, Yamaguchi, Miyoko, Kitano, Satsuki, Miyachi, Hitoshi, Itoh, Akihiro, Yoshida, Minoru, Tachibana, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630185/
https://ncbi.nlm.nih.gov/pubmed/28949961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007034
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