Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

Histone H3 lysine 9 (H3K9) methylation is unevenly distributed in mammalian chromosomes. However, the molecular mechanism controlling the uneven distribution and its biological significance remain to be elucidated. Here, we show that JMJD1A and JMJD1B preferentially target H3K9 demethylation of gene...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Kuroki, Shunsuke, Nakai, Yuji, Maeda, Ryo, Okashita, Naoki, Akiyoshi, Mika, Yamaguchi, Yutaro, Kitano, Satsuki, Miyachi, Hitoshi, Nakato, Ryuichiro, Ichiyanagi, Kenji, Shirahige, Katsuhiko, Kimura, Hiroshi, Shinkai, Yoichi, Tachibana, Makoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998703/
https://ncbi.nlm.nih.gov/pubmed/29526734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.02.002
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