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Synthesis of benzothiophene and indole derivatives through metal-free propargyl–allene rearrangement and allyl migration

An efficient base-catalyzed protocol for the synthesis of benzothiophene is described. The reaction proceeds via base-promoted propargyl–allenyl rearrangement followed by cyclization and allyl migration. Phosphine-substituted indoles can be synthesized by a similar strategy.

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Dettagli Bibliografici
Pubblicato in:Beilstein J Org Chem
Autori principali: Yao, Jinzhong, Xie, Yajie, Zhang, Lianpeng, Li, Yujin, Zhou, Hongwei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Beilstein-Institut 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629416/
https://ncbi.nlm.nih.gov/pubmed/29062405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.181
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