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Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration

The reversibility and strength of the previously established dimerization of the important glycopeptide antibiotic vancomycin in four different aqueous solvents (including a medically-used formulation) have been studied using short-column sedimentation equilibrium in the analytical ultracentrifuge a...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Phillips-Jones, Mary K., Lithgo, Ryan, Dinu, Vlad, Gillis, Richard B., Harding, John E., Adams, Gary G., Harding, Stephen E.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629194/
https://ncbi.nlm.nih.gov/pubmed/28983082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12620-z
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