Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanS(A)R(A) two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanS(A) sensory component has not hitherto been identified. Here we employ purified, intact...

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Publicado en:Sci Rep
Autores principales: Phillips-Jones, Mary K., Channell, Guy, Kelsall, Claire J., Hughes, Charlotte S., Ashcroft, Alison E., Patching, Simon G., Dinu, Vlad, Gillis, Richard B., Adams, Gary G., Harding, Stephen E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387412/
https://ncbi.nlm.nih.gov/pubmed/28397853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46180
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