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Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration

The reversibility and strength of the previously established dimerization of the important glycopeptide antibiotic vancomycin in four different aqueous solvents (including a medically-used formulation) have been studied using short-column sedimentation equilibrium in the analytical ultracentrifuge a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Phillips-Jones, Mary K., Lithgo, Ryan, Dinu, Vlad, Gillis, Richard B., Harding, John E., Adams, Gary G., Harding, Stephen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629194/
https://ncbi.nlm.nih.gov/pubmed/28983082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12620-z
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