Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency

Ex vivo gene therapy using lentiviral vectors (LVs) is a proven approach to treat and potentially cure many hematologic disorders and malignancies but remains stymied by cumbersome, cost-prohibitive, and scale-limited production processes that cannot meet the demands of current clinical protocols fo...

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Udgivet i:Mol Ther
Main Authors: Tran, Reginald, Myers, David R., Denning, Gabriela, Shields, Jordan E., Lytle, Allison M., Alrowais, Hommood, Qiu, Yongzhi, Sakurai, Yumiko, Li, William C., Brand, Oliver, Le Doux, Joseph M., Spencer, H. Trent, Doering, Christopher B., Lam, Wilbur A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628863/
https://ncbi.nlm.nih.gov/pubmed/28780274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.07.002
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