TLR9-Mediated Conditioning of Liver Environment Is Essential for Successful Intrahepatic Immunotherapy and Effective Memory Recall

Immune defense against hepatotropic viruses such as hepatitis B (HBV) and hepatitis C (HCV) poses a major challenge for therapeutic approaches. Intrahepatic cytotoxic CD8 T cells that are crucial for an immune response against these viruses often become exhausted resulting in chronic infection. We e...

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Publicado en:Mol Ther
Main Authors: Cebula, Marcin, Riehn, Mathias, Hillebrand, Upneet, Kratzer, Ramona F., Kreppel, Florian, Koutsoumpli, Georgia, Daemen, Toos, Hauser, Hansjörg, Wirth, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628774/
https://ncbi.nlm.nih.gov/pubmed/28716576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.018
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