Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys

Development of vaccines against mosquito-borne Flaviviruses is complicated by the occurrence of antibody-dependent enhancement (ADE), which can increase disease severity. Long-term delivery of neutralizing antibodies (nAbs) has the potential to effectively block infection and represents an alternati...

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Publicado no:Mol Ther
Main Authors: Magnani, Diogo M., Ricciardi, Michael J., Bailey, Varian K., Gutman, Martin J., Pedreño-Lopez, Núria, Silveira, Cassia G.T., Maxwell, Helen S., Domingues, Aline, Gonzalez-Nieto, Lucas, Su, Qin, Newman, Ruchi M., Pack, Melissa, Martins, Mauricio A., Martinez-Navio, José M., Fuchs, Sebastian P., Rakasz, Eva G., Allen, Todd M., Whitehead, Stephen S., Burton, Dennis R., Gao, Guangping, Desrosiers, Ronald C., Kallas, Esper G., Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628771/
https://ncbi.nlm.nih.gov/pubmed/28750738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.020
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