Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells

Chondroblastoma is a cartilaginous tumor that typically arises under 25 y of age (80%). Recent studies have identified a somatic and heterozygous mutation at the H3F3B gene in over 90% chondroblastoma cases, leading to a lysine 36 to methionine replacement (H3.3K36M). In human cells, H3F3B gene is o...

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Bibliographic Details
Published in:Cell Cycle
Main Authors: Fang, Dong, Gan, Haiyun, Wang, Heping, Zhou, Hui, Zhang, Zhiguo
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628648/
https://ncbi.nlm.nih.gov/pubmed/28129023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1281483
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