Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

Histone H3 lysine27-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. Here, we establish a Drosophila animal model for the pathogenic histone H3K27M mutation and show that its overexpression resembles Polycomb repressive complex 2 (PRC2) loss-of-function...

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發表在:Science
Main Authors: Herz, Hans-Martin, Morgan, Marc, Gao, Xin, Jackson, Jessica, Rickels, Ryan, Swanson, Selene K., Florens, Laurence, Washburn, Michael P., Eissenberg, Joel C., Shilatifard, Ali
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508193/
https://ncbi.nlm.nih.gov/pubmed/25170156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1255104
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