Inhibition of Androgen Receptor Nuclear Localization and Castration Resistant Prostate Tumor Growth by Pyrroloimidazole-Based Small Molecules

The androgen receptor (AR) is a ligand-dependent transcription factor that controls the expression of androgen-responsive genes. A key step in androgen action, which is amplified in castration resistant prostate cancer (CRPC), is AR nuclear translocation. Small molecules capable of inhibiting AR nuc...

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Pubblicato in:Mol Cancer Ther
Autori principali: Masoodi, Khalid Z., Xu, Yadong, Dar, Javid A., Eisermann, Kurtis, Pascal, Laura E., Parrinello, Erica, Ai, Junkui, Johnston, Paul A., Nelson, Joel B., Wipf, Peter, Wang, Zhou
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628124/
https://ncbi.nlm.nih.gov/pubmed/28655783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0176
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