High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

NK cell education is the process through which chronic engagement of inhibitory NK cell receptors by self MHC-I molecules preserves cellular responsiveness. The molecular mechanisms responsible for NK cell education remain unclear. Here, we show that mouse NK cell education is associated with a high...

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Pubblicato in:eLife
Autori principali: Marçais, Antoine, Marotel, Marie, Degouve, Sophie, Koenig, Alice, Fauteux-Daniel, Sébastien, Drouillard, Annabelle, Schlums, Heinrich, Viel, Sébastien, Besson, Laurie, Allatif, Omran, Bléry, Mathieu, Vivier, Eric, Bryceson, Yenan, Thaunat, Olivier, Walzer, Thierry
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Immunology and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628014/
https://ncbi.nlm.nih.gov/pubmed/28875936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26423
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