High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

NK cell education is the process through which chronic engagement of inhibitory NK cell receptors by self MHC-I molecules preserves cellular responsiveness. The molecular mechanisms responsible for NK cell education remain unclear. Here, we show that mouse NK cell education is associated with a high...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Marçais, Antoine, Marotel, Marie, Degouve, Sophie, Koenig, Alice, Fauteux-Daniel, Sébastien, Drouillard, Annabelle, Schlums, Heinrich, Viel, Sébastien, Besson, Laurie, Allatif, Omran, Bléry, Mathieu, Vivier, Eric, Bryceson, Yenan, Thaunat, Olivier, Walzer, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628014/
https://ncbi.nlm.nih.gov/pubmed/28875936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26423
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