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Immune suppressive mechanisms in the tumor microenvironment

Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients by a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells is orchestrated by the activity of a variety of stromal myeloid and lymphoid cells. Thes...

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Detalhes bibliográficos
Publicado no:Curr Opin Immunol
Main Authors: Munn, David H., Bronte, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627973/
https://ncbi.nlm.nih.gov/pubmed/26609943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2015.10.009
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