Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity

Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we demonstrate that high-fat diet (HFD)-induced obesity impairs CD8(+) T cell function in the murine TME, accelerating tum...

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Veröffentlicht in:Cell
Hauptverfasser: Ringel, Alison E., Drijvers, Jefte M., Baker, Gregory J., Catozzi, Alessia, García-Cañaveras, Juan C., Gassaway, Brandon M., Miller, Brian C., Juneja, Vikram R., Nguyen, Thao H., Joshi, Shakchhi, Yao, Cong-Hui, Yoon, Haejin, Sage, Peter T., LaFleur, Martin W., Trombley, Justin D., Jacobson, Connor A., Maliga, Zoltan, Gygi, Steven P., Sorger, Peter K., Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064125/
https://ncbi.nlm.nih.gov/pubmed/33301708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.009
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