Preferential interactions of trehalose, L-arginine.HCl and sodium chloride with therapeutically relevant IgG1 monoclonal antibodies

Preferential interactions of weakly interacting formulation excipients govern their effect on the equilibrium and kinetics of several reactions of protein molecules in solution. Using vapor pressure osmometry, we characterized the preferential interactions of commonly used excipients trehalose, L-ar...

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Publicado no:MAbs
Main Authors: Sudrik, Chaitanya, Cloutier, Theresa, Pham, Phuong, Samra, Hardeep S., Trout, Bernhardt L.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627590/
https://ncbi.nlm.nih.gov/pubmed/28758834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1358328
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