Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency

BACKGROUND: Cisplatin neuro-, oto-, and nephrotoxicity are major problems in children with malignant tumors, including medulloblastoma, negatively impacting educational achievement, socioemotional development, and overall quality of life. The blood-labyrinth barrier is somewhat permeable to cisplati...

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Detalhes bibliográficos
Publicado no:Fluids Barriers CNS
Main Authors: Dósa, Edit, Heltai, Krisztina, Radovits, Tamás, Molnár, Gabriella, Kapocsi, Judit, Merkely, Béla, Fu, Rongwei, Doolittle, Nancy D., Tóth, Gerda B., Urdang, Zachary, Neuwelt, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627439/
https://ncbi.nlm.nih.gov/pubmed/28974245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-017-0075-0
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